LSD (lysergic acid diethylamide) is one of the major drugs making up the hallucinogen
was discovered in 1938 and is one of the most potent mood-changing chemicals. It is
from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains.
LSD, commonly referred to as "acid," is sold on the street in tablets, capsules,
liquid form. It is odorless, colorless, and has a slightly bitter taste and is usually
taken by mouth.
Often LSD is added to absorbent paper, such as blotter paper, and divided into small
squares, with each square representing one dose.
The Drug Enforcement Administration reports that the strength of LSD samples obtained
from illicit sources ranges from 20 to 80 micrograms of LSD per dose. This is considerably
than the levels reported during the 1960s and early 1970s, when the dosage ranged from 100
200 micrograms, or higher, per unit.
The effects of LSD are unpredictable. They depend on the amount taken; the user's
mood, and expectations; and the surroundings in which the drug is used. Usually, the user
feels the first effects of the drug 30 to 90 minutes after taking it. The physical effects
include dilated pupils, higher body temperature, increased heart rate and blood pressure,
sweating, loss of appetite, sleeplessness, dry mouth, and tremors.
Sensations and feelings change much more dramatically than the physical signs. The user
several different emotions at once or swing rapidly from one emotion to another. If taken
in a large
enough dose, the drug produces delusions and visual hallucinations. The user's sense of
self changes. Sensations may seem to "cross over," giving the user the feeling
of hearing colors and
seeing sounds. These changes can be frightening and can cause panic.
Users refer to their experience with LSD as a "trip" and to acute adverse
reactions as a "bad trip."
These experiences are long - typically they begin to clear after about 12 hours.
Some LSD users experience severe, terrifying thoughts and feelings, fear of losing
control, fear of
insanity and death, and despair while using LSD. Some fatal accidents have occurred during
of LSD intoxication.
Many LSD users experience flashbacks, recurrence of certain aspects of a person's
without the user having taken the drug again. A flashback occurs suddenly, often without
warning, and may occur within a few days or more than a year after LSD use. Flashbacks
usually occur in people who use hallucinogens chronically or have an underlying
personality problem; however, otherwise healthy people who use LSD occasionally may also
have flashbacks. Bad trips and flashbacks are only part of the risks of LSD use. LSD users
may manifest relatively long-lasting psychoses, such as schizophrenia or severe
depression. It is difficult to determine the extent and mechanism of the LSD involvement
in these illnesses.
Most users of LSD voluntarily decrease or stop its use over time. LSD is not considered an
addictive drug since it does not produce compulsive drug-seeking behavior as do cocaine,
amphetamine, heroin, alcohol, and nicotine. However, like many of the addictive drugs, LSD
produces tolerance, so some users who take the drug repeatedly must take progressively
doses to achieve the state of intoxication that they had previously achieved. This is an
dangerous practice, given the unpredictability of the drug. NIDA is funding studies that
focus on the neurochemical and behavioral properties of LSD. This research will provide a
greater understanding of the mechanisms of action of the drug.
Extent of Use
Monitoring the Future Study (MTF)*
Since 1975, MTF researchers have annually surveyed almost 17,000 high school seniors
nationwide to determine trends in drug use and to measure attitudes and beliefs about drug
Over the past 2 years, the percentage of seniors who have used LSD has remained relatively
Between 1975 and 1997, the lowest lifetime use of LSD was reported by the class of 1986,
7.2 percent of seniors reported using LSD at least once in their lives. In 1997, 13.6
seniors had experimented with LSD at least once in their lifetimes. The percentage of
reporting use of LSD in the past year nearly doubled from a low of 4.4 percent in 1985 to
percent in 1997.
In 1997, 34.7 percent of seniors perceived great risk in using LSD once or twice, and 76.6
said they saw great risk in using LSD regularly. More than 80 percent of seniors
people trying LSD once or twice, and almost 93 percent disapproved of people taking LSD
Almost 51 percent of seniors said it would have been fairly easy or very easy for them to
if they had wanted it.
LSD Use by Students, 1997:
Monitoring the Future Study
|Used in the Past Year
|Used in the Past Month
National Household Survey on Drug Abuse (NHSDA)**
NHSDA reports the nature and extent of drug use among the American household popula tion
aged 12 and older. In the 1996 NHSDA estimates, the percentage of the population aged 12
and older who had ever used LSD (the lifetime prevalence rate) had increased to 7.7
percent from 6.0
percent in 1988. Among youths 12 to 17 years old, the 1996 LSD lifetime prevalence rate
percent, and for those aged 18 to 25, the rate was 13.9 percent. The rate for past-year
use of LSD
among the population ages 12 and older was 1 percent in 1996. Past-year prevalence was
among the age groups 12 to 17 (2.8 percent) and 18 to 25 (4.6 percent). The rate of
use in 1996 for those aged 18 to 25 was 0.9 percent, and it was 0.8 percent for 12- to
*MTF is an annual survey on drug use and related attitudes of America's adolescents that
in 1975. The survey is conducted by the University of Michigan's Institute for Social
is funded by NIDA. Copies of the latest survey are available from the National
Alcohol and Drug Information at 1-800-729-6686.
**NHSDA is an annual survey conducted by the Substance Abuse and Mental Health Services
Administration. Copies of the latest survey are available from the National Clearinghouse
Alcohol and Drug Information at 1-800-729-6686.